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o395_wt_cholera_wild_type
O395 Cholera wild type
Transmission electron microsope image of Vibrio choleraethat has been negatively stained. Vibrio choleraeis the bacteria responsible for the gastroinestinal disease cholera. In order to get the disease cholera, the bacteria must be able to colonize in the small intestine and a critical factor necessary for this colonization is the toxin-co-regulated pilus(TCP). 0395 is a wild type strain, showing the normal bundling of toxin-co-regulated pilus(TCP). Wild-type pili are clearly visible as 7 nm fibres that form bundles @ 0.20.3 m wide and 36 m long.
For more information, see the journal article: T.J. Kirn, M.J. Lafferty, C.M.P Sandoe and R.K. Taylor, 2000, "Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization", Molecular Microbiology, Vol. 35(4):896-910
To go to the article, click here.

JEOL TEM 100CX

Bacteria, TEM, Vibrio cholerae, pili, tcp
Tom Kirn, Ron Taylor, Louisa Howard